This paper investigates the robust reliable β-dissipative control for uncertain dynamical systems with mixed actuator faults via sampled-data approach. In particular, a more general reliable controller containing both linear and nonlinear parts is constructed for the considered system. Then, by applying the input delay approach, the sampling measurement of the digital control signal is transformed into time-varying delayed one. The aim of this paper is to design state feedback sampled-data controller to guarantee that the resulting closed-loop system to be strictly (Q, S, R)-β-dissipative. By constructing appropriate Lyapunov function and employing a delay decomposition approach, a new set of delay-dependent sufficient stabilization criteria is obtained in terms of linear matrix inequalities (LMIs). Moreover, the obtained LMIs are dependent, not only upon upper bound of time delay but also depend on the dissipative margin β and the actuator fault matrix. As special cases, and passivity control performances can be deduced from the proposed dissipative control result. Finally, numerical simulation is provided based on a flight control model to verify the effectiveness and applicability of the proposed control scheme.