This paper introduces a new type of synchronization scheme, referred to as difference synchronization scheme, wherein the difference between the state variables of two master [slave] systems synchronizes with the state variable of a single slave [master] system. Using the Lyapunov stability theory and the active backstepping technique, controllers are derived to achieve the difference synchronization of three identical hyperchaotic Liu systems evolving from different initial conditions, as well as the difference synchronization of three nonidentical systems of different orders, comprising the 3D Lorenz chaotic system, 3D Chen chaotic system, and the 4D hyperchaotic Liu system. Numerical simulations are presented to demonstrate the validity and feasibility of the theoretical analysis. The development of difference synchronization scheme has increases the number of existing chaos synchronization scheme.