This research is about “controversial analysis of a refrigeration vapor-compression cycle,” using R22, and environmentally friendly hydrofluorocarbon (HFC) refrigerants such as R134a, R407c, and R410a in various climatic conditions. For initiation, a complete database was provided for thermophysical properties of the refrigerants’ performances. Then, P–h, s–T, s–h equations are derived in matlab and Excel with the maximum R2. Meanwhile, five climatic conditions (from hot to cold state) are assumed. Consequently, temperature, pressure, enthalpy, and entropy of the cycle states are illustrated for aforesaid conditions as per working fluids properties in the form of quadripartite diagrams. Subsequently, the cycle was analyzed thermodynamically. The coeffcient of performance (COP) was performed for refrigeration (cooling procedure), heat pump (heating procedure), and both heating and cooling for both standard and actual conditions. Afterward, the calculation was performed for parameters like energy efficiency ratio (EER), heat rejected ratio (HRR), capacity, energy, exergy, irreversibility, and exergy destruction ratio (EDR) of each system component according to the first and second laws of thermodynamics, individually. Derived and calculated values in each session illustrated in 3D diagrams on which TEvap s, TCond s and working fluids for each assumed climatic condition can be distinguished easily. A concise analytic study was performed for the increasing and decreasing in values. Forecast for two steps upper and lower than all values derived for trending. Making a trend for indicating either positive or negative inclines of the values and proposing a development for all similar cycles can be considered as the novelty of this research.