The combustion of 2,4,4-trimethyl-1-pentene (diisobutylene, C8H16), which is a biofuel and a component of surrogate fuels, is examined in this work. Carbon monoxide time–histories and ignition delay times are collected behind reflected shock waves utilizing a shock tube and mid-infrared laser absorption spectroscopy. Measurements were obtained near 10 atm pressure during stoichiometric oxidation of 0.15%C8H16/O2/Ar. Simulated results from chemical kinetic models are provided, and sensitivity analyses are used to discuss differences between models for both ignition delay times and carbon monoxide formation. In addition, laminar burning speeds are obtained at 1 atm, 428 K, and equivalence ratios, phi, between 0.91 and 1.52 inside a spherical chamber facility. Measured burning speeds are found to be less than that of ethanol over the equivalence ratio span. Burning speed measurements are compared to predictions of chemical kinetic mechanisms and are in agreement for the richest conditions; however, at lean conditions, the model predicts a far slower-burning speed. The maximum burning speed occurs at an equivalence ratio of 1.08 with a magnitude of 0.70 m/s. The current work provides the crucial experimental data needed for assessing the feasibility of this biofuel and for the development of future combustion chemical kinetics models.